This post is also an argument for why AI won't bail us out of regulatory reform to make in-human testing easier. In fact, in-human data from trials would be the best complement to AI and one way to avoid the "slop trap" by training it on meaningful results.

Ruxandra has an excellent new post about how the real bottleneck to new medicines is human PoC. Much of the discourse about AI + biology (not Ruxandras post) takes as axiomatic that there nothing to be done to accelerate trials. In fact there is plenty to be done. See China. The real discussion should be to recognize that it is very possible that AI will make huge strides in the development of new medicines, but that the country that enables this through regulatory reform stands to gain most of this value. Right now that is looking likely to be China. Let’s do something about it.

New York City’s decades-long experiment of building less housing per capita than almost any other large city in America has been an unmitigated disaster.

Next-gen strategiy to comply w/ BMR requirements: - split a proposed building into two legally separate entities - finance building as two projects: a 100% affordable project, and a market-rate project @aarmlovi has told me some NYC developers are doing it too 1/5

vravo bince

He did in my neighborhood! Then the construction dragged on… and on… for years…. Prices increased, life got worse for ordinary people, and still no new projects actually opened. By October 2024, people were vandalizing Biden’s name on the signs.

That’s it??

Tell me more

can’t believe this actually happened

incredible

And if he wasn’t in the senate literally none of those things would’ve passed

Winsome Sears went all in on it and it backfired because it made her look obsessed

What the public really *does* care about, according to Stamps's studies, is: - (1) maintaining the stylistic homogeneity of homogeneous block faces, - (2) architectural decoration, - (3) trees/greenery. /7

- The city passed a bunch of rules about setbacks, stepbacks, break up the massing. Stamps finds that people don't care about this stuff. Worse, "breaking up the massing" often introduces asymmetries, yet the public prefers symmetry. /6

What came next was one regulatory misfire after another. - The city strictly controlled heights, but Stamps's studies find that public barely objects to taller infill until the new building is approx 2x the height of its neighbors /4

I stumbled across the work of Arthur E. Stamps III this morning and, wow, my eyes have been opened! He's was (is?) an architect in San Francisco who wrote scores of academic papers on the mass public's aesthetic preferences & the failure of "design review" to serve them. 🧵/18

honestly my number one ask of SFMTA that would cost zero money is just fewer stops. it’s ridiculous how slow it makes some routes

Gov Hochul is right! NYers love that Mr. Mamdani represents transit users & understands the city's overall affordability crisis But when you ask bus riders what would increase their satisfaction, almost nobody says lower fares first Happy to pay, just spend it all on service

Who else do you think can win as a D in West Virginia

If we didn’t have Joe Manchin we would’ve never passed the IRA, the ARP, etc