MIT have developed bioelectronic devices that, after IV injection, are trafficked through the circulatory system and implant autonomously in brain regions of inflammation.
They also demonstrate that they enable wirelessly controlled focal stimulation of deep brain regions such as ventrolateral thalamic nucleus in the rodent brain providing a nonsurgical brain implant for focal neuromodulation that takes advantage of immune cells’ natural trafficking to sites of inflammation.
They have given electronics that circulate through the vasculature the name ‘Circulatronics’.
Realization of the Circulatronics brain stimulator requires:
(1) The development of efficient wireless free-floating electronic devices that are miniaturized to fit inside the vasculature.
(2) The circulation of these devices without being eliminated from the bloodstream.
(3) Capabilities in the recognition of, and self-implantation in, desired brain regions.
To overcome these challenges, they have built wireless optical energy harvesting electronic devices that are subcellular sized and self-standing with high efficiency.
To achieve point (1) they created hybrids with living immune cells.
(Literal Cyborgs -
ieee-ras.org/cyborg-bionic-s…)
To fit and freely move inside the vasculature without clogging, the size of Circulatronics devices must be similar to or smaller than that of the circulating cells (for reference, a circulating cell such as monocyte has a diameter of 12–18 µm).
They developed something called subcellular-sized wireless electronic devices (SWEDs) that are free-floating and that can convert extracorporeally applied fields to electrical energy to enable electrical neuromodulation.
medicalxpress.com/news/2024-…
news.mit.edu/2024/wearable-d…
While there are different modalities for wireless energy harvesting (such as radio frequency, electromagnetic, optical or acoustic) each with its unique characteristics, they focused primarily on the photovoltaic principle, which involves wireless powering via optical fields.
This is because optical modalities provide high spatio-temporal resolution, penetration depth of several centimeters in the human head with intact skull and have already been used for clinical studies.
static-content.springer.com/…
Moreover, photovoltaic devices generate DC potentials, eliminating the need for any rectifying circuits (saving on-chip area and avoiding circuit complexity).
Other modalities can also be employed in future for Circulatronics technology, based on user-defined requirements. Although photovoltaics have been applied previously for neuromodulation (
nature.com/articles/s41565-0…), this study by MIT investigates subcellular-sized free-floating photovoltaic devices compatible with circulation through bloodstream for in vivo electrical brain stimulation.
Moreover, none of the previous photovoltaic devices or implants with other modalities (optical, electrical, radio frequency, magnetic or acoustic) have been demonstrated for brain stimulation with high spatial resolution without surgery.
MIT used organic semiconductors (
onlinelibrary.wiley.com/doi/…) to leverage the photovoltaic effect, as they have unique advantages such as narrow bandwidth for enabling multiplexing, high optical absorption coefficients, mechanical flexibility allowing better interfacing with soft biological systems and biocompatibility.
They also provide ease of fabrication and compatibility with complementary metal-oxide-semiconductor back-end-of-line processing creating opportunities for integrating advanced functionalities in the future.
sciencedirect.com/science/ar…
nature.com/articles/ncomms21…