DIFOCCULT-3 RCT shows that an #AI-assisted ECG interpretation accelerates NSTEMI-OMI detection by several hours and hints at improved short-term outcomes! #TCT2025 @AslangerE @PMcardioApp

Oct 26, 2025 · 12:41 AM UTC

Fascinating. Are the data in this forest plot also limited to NSTEMI subgroup?
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Forest plot is for the entire cohort
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Something I've got to ask: Achieving Balloon time of ~5 hours in NSTEMI seems far better than most centers do, so aren't you afraid that the true effect of OMI detection will be masked? ( If you think of the typical 24 hours it takes to get NSTEMI to PCI)
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The important part is NSTEMI-OMIs in the AI group made it to the CCL in guideline interval <90 mins. It is not entirely true that all NSTEMI-OMIs are cathed in 24 hours, many STEMI equivalents are cathed couple hours later as STEMI that was “not diagnostic initially”
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OMI without STE includes patients with varying collateral sufficiency. Those with near-adequate collaterals (e.g., acute occlusion of chronically stenotic vessel) may benefit less from ultra-fast door-to-balloon times (similar to the troponin and LVEF on the forest plot). But catching posterior MI, often missed entirely, is a clear win. Your explainable ECG model could help distinguish these scenarios. Congrats on your work!
Thank you! There is an angiographic core-lab trial ongoing that will shed light precisely on the characterization of OMI. Collaterals are only a minor part; more critical are missed posterior OMIs without collaterals, but even delayed recognition of anterior STEMI. It depends on your definition of NSTEMI-OMI pubmed.ncbi.nlm.nih.gov/4071…
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