Squidiff: a diffusion-based model to predict transcriptome response to perturbations. nature.com/articles/s41592-0…

Nov 7, 2025 · 2:41 PM UTC

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Also check out the Research Briefing on this work, here: nature.com/articles/s41592-0…
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Replying to @naturemethods
Simply amazing!
Replying to @naturemethods
not proteomics, but paths thru the "folding funnel" must be not merely convergent, but convergent even under "perturbation", otherwise the system wouldn't reliably produce stable behavior biophysics/etc needs hermitian product spaces. they open up "pocket spaces"
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