Signal Transduction and Targeted Therapy (STTT) | A Nature Portfolio Journal | Impact Factor 52.7 | CiteScore: 58.6 | Peer-reviewed | Open Access |
Joined December 2016
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Sigtrans now extends sincere welcome to #research_highlights that summarize top papers from Cell, Nature or Science etc. Researchers interested in related topics please contact our editorial office (sttt@scu.edu.cn).
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This review explores the multifactorial pathogenesis of #DiabeticNeuropathy and highlights emerging diagnostics, #neuroprotective strategies, and therapeutic targets—including gene and #StemCellTherapies. #DiabetesMellitus
#OpenAccess in #STTT: doi.org/10.1038/s41392-025-0…
An overview of meningeal lymphatic vessels—their development, structure, and function—as well as the molecular mechanisms of injury, links to #CNS diseases, and factors regulating meningeal lymphatic function.
#STTT #OpenAccess: doi.org/10.1038/s41392-025-0…
Combining the mTORC1/2 inhibitor #onatasertib with the #PD1antibody #toripalimab offers a promising efficacy in advanced #SolidTumors—especially recurrent or #MetastaticCervicalCancer—regardless of #PDL1 expression. @antengene
#OpenAccess in #STTT: doi.org/10.1038/s41392-025-0…
#REGOMUNE—a phase II #ClinicalTrial of #Regorafenib + #Avelumab in advanced 'cold' #SoftTissueSarcoma—shows that the therapy modulates the #TumorMicroenvironment and boosts immune-mediated tumor destruction.
#STTT #OpenAccess: doi.org/10.1038/s41392-025-0…
#MetabolicReprogramming drives #Sorafenib resistance in #HCC through enhanced glycerolipid remodeling and antioxidant defenses, identifying #DLactate as a response marker and glycerol as a resistance indicator. @LaStatale @IEOufficiale
#OpenAccess in #STTT: doi.org/10.1038/s41392-025-0…
Using the MiLi-FE method, this #STTT study developed AR@ENV—microglia-derived #Nanocarriers co-loaded with #Rapamycin & AR7—that promotes synchronized activation of #Macroautophagy & #CMA in #AlzheimersDisease therapy.
#OpenAccess: doi.org/10.1038/s41392-025-0…
#Olverembatinib, a novel #MultiKinaseInhibitor, demonstrates strong efficacy and safety in SDH-deficient GISTs resistant to #TKIs, mechanistically suppressing #LipidUptake and #CD36-associated tumorigenic pathways. #GISTs #CD36
#OpenAccess in #STTT: doi.org/10.1038/s41392-025-0…
A novel long-acting C5a-blocking cyclic peptide blocks the C5a–C5aR1 interaction to suppress #Hyperinflammation & maintain #ImmuneHomeostasis while reducing #Sepsis-induced organ dysfunction. @FudanUniversity
#STTT #OpenAccess: doi.org/10.1038/s41392-025-0…
This review highlights the role of #ProteinKinases in #NeurodegenerativeDiseases and explores kinase-targeted strategies—including inhibitors, #AntisenseOligonucleotides, and #GeneTherapy—for early intervention & disease management. @2024_HUST @SCUCN
#STTT: doi.org/10.1038/s41392-025-0…
STYK1 hyperactivates Wnt/β-catenin pathway in APC-independent #PancreaticCancer via GSK3β sequestration, suggesting that disrupting STYK1–β-catenin or STYK1–GSK3β interactions may suppress tumor progression. @UAlberta
#STTT #OpenAccess: doi.org/10.1038/s41392-025-0…
AACR Associate Members: Apply by Nov 18 for the AACR Scholar-in-Training Awards, which support early-career scientists attending #AACR26. Special opportunities available for #AACRScholars working on brain & kidney cancer as well as DSRCT. Learn more: brnw.ch/21wXiPK
Signal Transduction and Targeted Therapy (STTT) retweeted
How can AI accelerate the path toward truly personalised cancer care?
At #ESMOAI25, the session “AI-based biomarkers for precision oncology” will explore AI’s role in predicting drug activity & developing precision biomarkers.
👉 esmo.org/meeting-calendar/es…
#PrecisionOncology #HealthAI
🤖 AI is accelerating #CancerDiagnostics - improving both speed and accuracy.
👉 Learn more in the session “AI-based biomarkers for precision oncology” at #ESMOAI25 in Berlin.
esmo.org/meeting-calendar/es…
#DigitalOncology #PrecisionOncology #HealthAI
Signal Transduction and Targeted Therapy (STTT) retweeted
Breaking the Stromal Barriers to Improve Pancreatic Cancer Therapy Through the B-SMART Project - Nelson Dusetti
@NelsonDusetti
oncodaily.com/voices/nelson-…
#Cancer #Medicine #Health #Oncology #OncoDaily #PancreaticCancer #MedNews #MedEd #MedX
This review highlights lactate’s role in shaping the #TumorMicroEnvironment and discusses therapeutic strategies targeting #LactateDehydrogenase and MCT to exploit #LactateMetabolism as a strategy to enhance #CancerTherapy effectiveness. @sjtu1896
#STTT: doi.org/10.1038/s41392-024-0…
Researchers from @uiccom show that #UvealMelanoma cells with a GNA11Q209L or GNAQQ209Lmutation secrete #VEGF to induce #EndothelialPermeability, facilitating UM cell transmigration across the endothelium.
#OpenAccess: doi.org/10.1038/s41392-025-0…
Single-nucleus and #SpatialTranscriptomics reveal how #mesothelial and immune cell interactions drive #CVB3-induced #FulminantMyocarditis, identifying the IFN-γ/Spi1 axis as a key therapeutic target and demonstrating IVIG’s efficacy. @2024_HUST
#STTT: doi.org/10.1038/s41392-025-0…
Src inhibitors reverse MCL-1 inhibitor-induced MCL-1 accumulation in AML cells, by promoting degradative #Ubiquitination, disrupting STAT-3-mediated transcription, and inducing NOXA-mediated MCL-1 degradation.
#STTT #OpenAccess: doi.org/10.1038/s41392-025-0…
This review highlights AXL as a key #oncogenic driver and #antiviral target, detailing its roles in #tumor progression, immune evasion, and #DrugResistance, and explores emerging AXL-targeted therapies for improving outcomes in #cancer.
#OpenAccess #STTT: doi.org/10.1038/s41392-024-0…
Reviewing the cellular response & cross-talk in #LiverRepair & regeneration, the signaling pathways involved, & #MetabolicReprogramming of liver cells, with insights into innovations in #Diagnostic & therapeutic strategies.
#STTT #OpenAccess: doi.org/10.1038/s41392-024-0…
This review examines #Copper biology and the emerging role of #Cuproptosis in #Cancer, outlining its mechanisms, dual roles in #tumor regulation, and therapeutic promise of copper modulation for future #Anticancer strategies.
#OpenAccess in #STTT: doi.org/10.1038/s41392-025-0…
