IL-6 and IL-8 elevations after co-administration of COVID-19 and influenza vaccines are associated with lower anti-spike IgG titers at three and six months post-vaccination 🔥For those still in doubt: don’t take both vaccines together( →4-6 weeks). ➡️"Coordinated activation of cytokines 5 days after dual COVID-19 and Flu vaccination." ➡️"The IL-6 and IL-8 increase negatively correlated with anti-S IgG at 3- and 6-months." ➡️Subsequently the "Inflammatory cytokine response may limit persistence of vaccine-induced antibody response." ‼️So, co-administration may impair long-term COVID-19 antibody persistence due to early inflammatory cytokines (e.g., IL-6, IL-8) negatively correlating with mid-term IgG titers. sciencedirect.com/science/ar…

Nov 7, 2025 · 9:20 AM UTC

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Replying to @HarrySpoelstra
How bad is it when you take them two weeks apart?
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No, that's not bad, it's probably better!
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Replying to @HarrySpoelstra
Harry, you might want to look at this article (and the other data out there) and comment as well? Paywalled, so does the study you posted say IL-6 and 8 in everyone or just those who showed unusually high elevation? academic.oup.com/ofid/articl…

Concurrent Administration of COVID-19 and Influenza Vaccines Enhances Spike-Specific Antibody...

AbstractBackground. The bivalent COVID-19 mRNA boosters became available in fall 2022 and were recommended alongside the seasonal influenza vaccine. Howeve

academic.oup.com
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IgG1 as their parameter, is a different approach from the IL-6 and IL-8 in the above study! They don't contradict each other. They only show that some might not benefit from the dual shot! Another reason to separate the 2, AE separation.😉
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Replying to @HarrySpoelstra
Yet they kept advertising "a shot in each arm". Then people wonder why trust has been lost. thelancet.com/journals/lanep…
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👀
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Replying to @HarrySpoelstra
pmc.ncbi.nlm.nih.gov/article…

Concurrent administration of COVID-19 and influenza vaccines enhances Spike-specific antibody...

The bivalent COVID-19 mRNA boosters became available in fall 2022 and were recommended alongside the seasonal influenza vaccine. However, the immunogenicity of concurrent versus separate administra...

pmc.ncbi.nlm.nih.gov
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>1y old preprint, no peer-review version yet? 😬
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Replying to @HarrySpoelstra
Is this equally true for Novavax vs the MRNA Covid vaccines?
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Yes, why not?😉
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Replying to @HarrySpoelstra
Well, some say so and Others say so… This Paper states quite the Contrary: 🤔 pmc.ncbi.nlm.nih.gov/article…
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Replying to @HarrySpoelstra
This is very interesting. If the vaccinations are given on separate days, some reduction in uptake due to opportunity loss would be expected.
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Replying to @HarrySpoelstra
👀
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Replying to @HarrySpoelstra
How about with the flu and RSV Vaccines? Think it's a smart approach to wait in between all vaccines?
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Replying to @HarrySpoelstra
If they aren’t testing them in combination nor following up properly after millions of doses being administered then why say to take them together?
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Replying to @HarrySpoelstra
Is there a falloff in acheived immunisation rate if the vaxes are not offered together?
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Replying to @HarrySpoelstra
I wish I knew this before. We had them both today. I asked different doctors and they all said that it was ok to take them at the same time. Some of them even said it would be easier to get it done all in one day. 😖
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Replying to @HarrySpoelstra
Can get access to the full paper w/o an institution. Does discussion suggest better timing? Is that where you get the (impractical, given coinciding access & higher risk seasons) wide 4-6 wk gap suggestion? And which should best come first?
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Replying to @HarrySpoelstra
Great! Pharmacists are recommending getting both at once. How does this information get to them? Personally, I got Covid and flu vaccines two weeks apart and would not consider getting two vaccines at the same time. My adult daughter got both at once and had severe side effects.
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Replying to @HarrySpoelstra
Oops, wish I would have known that last week.
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Replying to @HarrySpoelstra
Useful one! Though I had already decided to focus on flu alone. 🤓
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Replying to @HarrySpoelstra
This sounds like a really important study and there is probably no one left at the CDC to get to word out to pharmacists who actively urge people to get both together. 💔😪🤬 @dr_demetre
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Replying to @HarrySpoelstra
Poke @C_A_G0101 @Panda31808732 @SaiyanBio est ce la peine de tag Santé Gouv pour qu’ils changent la campagne ?
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Replying to @HarrySpoelstra
Too late for me this year but I'll remember for next time. Thanks!
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Replying to @HarrySpoelstra
@DonEford - comment from the Novavax side?
Replying to @HarrySpoelstra
N=29, the differences in titers are minimal, the scattergrams look like starry skies, and negative correlation is inferred at R<0.46 with no declared reason to assume a linear model. A grain of salt is advised to be taken (and that is a very benevolent statement).
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Replying to @HarrySpoelstra
This seems very important - unfortunately access to the whole article is behind a paywall.
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Replying to @HarrySpoelstra
It's never made sense to receive multiple vaccinations at once. Example of when things are not logical, why listen to "the experts" who are not experts or never bothered to study that. Mostly we never study combinations of variables, yet we must.
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Replying to @HarrySpoelstra
For 2 autumns, for no reason other than a desire to avoid shots in both arms and discomfort for 48 hours, I spaced mine 5 weeks apart. I advised friends in my demographic to do same. Apparently, the science supports the decision. Can you amplify why in lay terms?
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Replying to @HarrySpoelstra
Very interesting.
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Replying to @HarrySpoelstra
When I did get both flu and COVID vaccines I had them 6-8 weeks apart.
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