I'm not taking a stance on whether inflammation drives cancer, but I will say it's very true that GLP-1 drugs reduce inflammation—a lot! Tirzepatide at any dose greatly reduced levels of high-sensitivity C-reactive protein and interleukin-6, two important inflammation markers:
Simone Syed @SimoneSyed
Nov 3
Replying to @cremieuxrecueil
Chronic inflammation is a driver of cancer. Glp1s help mitigate that fr

Nov 3, 2025 · 5:55 PM UTC

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I have actually had people thank me for getting them on this stuff precisely because they had inflammation issues that these drugs *immediately* solved for them. Here's an example I've posted before: this man's back pain was cured!
Crémieux
 @cremieuxrecueil
Aug 4
Over the last few months, I've received hundreds of stories about people's lives being changed by GLP-1RAs. This recent one took me aback. A subscriber had their back pain wiped out by retatrutide, enabling a return to healthy habits, and more!
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Source: link.springer.com/article/10…

Anti-inflammatory effects of tirzepatide: a systematic review and meta-analysis

Reviews in Endocrine and Metabolic Disorders - Tirzepatide, a dual GIP and GLP-1 receptor agonist, has shown significant metabolic benefits and weight reduction, but its anti-inflammatory effects...

link.springer.com
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Tweeting about this topic might've brought this into my feed:
Daniel J Drucker @DanielJDrucker
Nov 3
How do GLP-1 medicines interact with immune cells to reduce #inflammation? From T cells, to the brain, #weightloss and much more, there is no simple unifying one size fits all pathway. "Sometimes we find as many as six impossible things before breakfast" jci.org/articles/view/194751
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Replying to @cremieuxrecueil
Currently taking slowing coming off my BP meds, so thankful.
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Hell yeah
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Replying to @cremieuxrecueil
Is this directly from the GLP-1s? Or is it the result of calorie deficit?
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There is a direct anti-inflammatory effect and an indirect weight loss-based effect. From this chart, you can see that the direct effect dominates though, since different doses return similar anti-inflammatory effects despite large differences in weight loss.
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Replying to @cremieuxrecueil
cool! independent of losing weight?
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Largely!
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Replying to @cremieuxrecueil
Your thread is going viral! #TopUnroll threadreaderapp.com/thread/1… 🙏🏼@warriors_mom for 🥇unroll

Thread by @cremieuxrecueil on Thread Reader App

@cremieuxrecueil: I'm not taking a stance on whether inflammation drives cancer, but I will say it's very true that GLP-1 drugs reduce inflammation—a lot! Tirzepatide at any dose greatly reduced...

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Replying to @cremieuxrecueil
Aw, my notifications didn't post the qt 🥰
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Replying to @cremieuxrecueil
@MLeavitt90086
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Replying to @cremieuxrecueil
@threadreaderapp unroll
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Replying to @cremieuxrecueil
Wondering if I can get the inflammation reduction benefits without losing weight if I take these.
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Replying to @cremieuxrecueil
Let's go 🚀 Send DM 💯💎
Replying to @cremieuxrecueil
I’ve heard anti inflammatories reduce muscle growth. Seems reasonable that this would too?
Replying to @cremieuxrecueil
it is known that inflammation is facilitating tumor initiation and progression
Replying to @cremieuxrecueil
Thoughts on dosing if you're trying to do lean gains?
Replying to @cremieuxrecueil
Replying to @cremieuxrecueil
Replying to @cremieuxrecueil
Tirzepetide got me to a 22 BMI, after DECADES of obesity. I'm forever grateful to whomever discovered it.
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Replying to @cremieuxrecueil
My husband has neuropathy in his feet from a stem cell transplant. He could not feel his feet. He now says he can feel them more and more while using Ozempic. Side effect bonus.
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Replying to @cremieuxrecueil
Anything that drives growth hormones will drive cancers receptive to those, like IGF-1 & breast and prostate. When we speak in generalities on cancer we lose the mark. It’s a complex disorder with no one size fits all approach. Each type has its weaknesses. Being unhealthy and obese is probably horrible for surviving any type, though.
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Replying to @cremieuxrecueil
@grok does GLP-1 inhibitor reduce inflammation and what are the mechanisms of action?
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Replying to @cremieuxrecueil
Is it the drug or the weight loss which is no longer fueling inflammation?
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Replying to @cremieuxrecueil
The everything drug strikes again!
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Replying to @cremieuxrecueil
Being severely overweight leads to all sorts of inflammation. I bet people who diet properly exercise regularly have lower inflammation as well.
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Replying to @cremieuxrecueil
Has it shown how much it decreases at microdoses? 500mcg le less ?
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Replying to @cremieuxrecueil
Best place to get this online for anti-inflammation purposes? TIA for response.
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Replying to @cremieuxrecueil
Question: have any studies been done on whether GLP-1 agonists could potentially be used as treatments for inflammatory autoimmune diseases like rheumatoid and psoriatic arthritis, lupus, ulcerative colitis, etcetera?
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Replying to @cremieuxrecueil
Weight loss increases circulating Arachidonic acid, just like statin use. Both also reduce inflammation. The chronic inflammation observed in obesity is driven by an Arachidonic acid deficiency.
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Replying to @cremieuxrecueil
Giving into weakness will not solve our problems and these drugs are just that. Hippocrates and Socrates already figured it out, good food and excercise.
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Replying to @cremieuxrecueil
is this better than traditional anti-inflammatories? I don't need the weight loss but could use some something better that ibuprofen with inflammation
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Replying to @cremieuxrecueil
@grok what's the causal pathway?
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Replying to @cremieuxrecueil
@grok what are the side effects of Tirzepatide?
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