Entrepreneur, CEO @ Teiko | “We put the ‘trap’ in ‘entrapreneur’” -Central Cee

San Francisco, CA
Joined February 2013
A Top 10 pharma developer came by our booth at SITC, and quite literally pulled a TON of TokuKit brochures off the table. ("I just love this", she said.)
This is a good moment to take the TSA and FAA private.
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Drug CFOs hate spending money on panel validation, but don’t mind spending money on panel runs.
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Last line was a bar tho
Replying to @RolandForTexas
You are a taker, not a maker. All you’ve done your whole life is take from the makers of the world. The zero-sum mindset you have is at the root of so much evil. Once you realize that civilization is not zero-sum and that it is about making far more than one consumes, then it becomes obvious that the path to prosperity for all is just let the makers make. Regarding Tesla, the reality is that I have been given nothing. However, if I lead Tesla to become the most valuable company in the world by far and it stays that way for 5 years, shareholders voted to award me 12% of what is built. Anyone who wants to come along for the ride can buy Tesla stock. If Tesla “merely” becomes a $1.999 trillion dollar company, I get nothing. This is a great deal for shareholders, which is why they voted so overwhelmingly to approve this, for which I am immensely grateful. And they did so by a margin far more than you won your political seat.
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Free market TSA. Imagine the equivalent of Wiz.io running physical security.
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Long Island barbers have better Mamdani analysis than “analysts”
AI will break the stranglehold paperwork has had on medicine.
Maybe it’s a hot take on here, but I still think medicine is a great field to go into
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The argument that “Zohran is a communist” so don’t vote for him, will be like the “Trump is a fascist” argument. It doesn’t work. In fact, people who hear it roll their eyes. Instead, the argument should be “Gottis and Gambinos shot me, but couldn’t kill me. Vote Sliwa.”
Replying to @aptaube
Each according to their need, each according to their ability
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AI for Legos that don’t hobble you when you step on them.
Sunshot is the new moonshot.
Our TPUs are headed to space!  Inspired by our history of moonshots, from quantum computing to autonomous driving, Project Suncatcher is exploring how we could one day build scalable ML compute systems in space, harnessing more of the sun’s power (which emits more power than 100 trillion times humanity’s total electricity production). Like any moonshot, it’s going to require us to solve a lot of complex engineering challenges. Early research shows our Trillium-generation TPUs (our tensor processing units, purpose-built for AI) survived without damage when tested in a particle accelerator to simulate low-earth orbit levels of radiation. However, significant challenges still remain like thermal management and on-orbit system reliability.  More testing and breakthroughs will be needed as we count down to launch two prototype satellites with @planet by early 2027, our next milestone of many. Excited for us to be a part of all the innovation happening in (this) space!
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Crucible era.
the value of simply being in San Francisco 2020-2022 was absolutely astronomical
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PTRS seems like an elaborate McKinsey fiction. Is it real?
This is a decent example to understand dosing effects.
I'm not taking a stance on whether inflammation drives cancer, but I will say it's very true that GLP-1 drugs reduce inflammation—a lot! Tirzepatide at any dose greatly reduced levels of high-sensitivity C-reactive protein and interleukin-6, two important inflammation markers:
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Sliwa still the most NYC mayor. Got shot by the Gottis and Gambinos and lived. No security.
Ramji Srinivasan b/ruv retweeted
what did y’all think Kardashev Type II meant ? vibes ? papers? essays? losers.
Replying to @rmcentush
Starship could deliver 100GW/year to high Earth orbit within 4 to 5 years if we can solve the other parts of the equation. 100TW/year is possible from a lunar base producing solar-powered AI satellites locally and accelerating them to escape velocity with a mass driver.
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Every Phase 1 should ingest all the PD data and figure out which metrics create a good ROC.
Heard building a high-plex 25+ marker flow panel is "not very challenging" these days. 😉 It's just a few simple steps: 1. Make your marker list. 2. Group them by expression level. 3. Check spectral overlap on a website. 4. Find the exact antibody + fluorochrome + clone combo you need (hopefully it exists!). 5. Get all your reagents. 6. Titrate every... single... one. 7. Make sure you have a test sample that's positive for all 25 markers. 8. Standardize them all and make sure their spectra actually don't overlap. 9. Realize some antibodies "don't work well." 10. Go back and try different ones from different vendors. 11. If those aren't available, just "make adjustments" to your whole panel. 12. Run all your controls. 13. Do a "few refinements." And in just 3 short months, you're all set! "Eventually it works."
Red line is where drug developers are for clinical trial recruitment. And each patient costs $150K+ a pop to recruit. towardsdatascience.com/roc-c…
The Justin Bieber ATLANTA episode has to be Donald Glover’s finest work.