Hybrid immunity not protective, may worsen risk of infection 48-fold increased risk of getting a repeat Omicron infection among those who had prior Omicron infection Large study from McMaster University Canada on vaccinated older adults, includes immune response details👇 1/5

Made a lot of smash burgers and a very large kale salad

Nic shared a German paper he considers a landmark “red-light special 🚨,” claiming that “86% of PCR-positive cases were not real infections.” I encourage everyone to read the paper carefully and evaluate how the authors reach this conclusion — particularly the assumptions underlying their analysis and whether those assumptions are justified. The authors essentially offset an estimate of the baseline IgG seropositivity in week 10 of 2020 and then compute a ratio R = (weekly % IgG seropositivity) / (cumulative sum of weekly PCR positivity rates). They treat the numerator as the true proportion ever infected and the denominator as the proportion inferred from PCR testing. They then assume that any R < 1 must be caused entirely by PCR false positives. Because they find R ≈ 1/7, they infer that 6 / 7 = 86% of positive PCR tests were “not real infections.” This reasoning is deeply flawed. In real-world data, there is no reason to expect R = 1.0 unless all of the following conditions are simultaneously true: 1. IgG testing is completely random. 2. PCR testing is completely random. 3. PCR testing rates are constant over time. 4. No individual is ever tested twice by PCR. 5. No one is ever reinfected. 6. No one is vaccinated. 7. Every infection leads to detectable IgG antibodies. 8. No one loses antibodies over time (seroreversion). 9. IgG tests are 100% sensitive and specific. 10. PCR tests are 100% sensitive and specific. Only if all ten conditions held could we expect R = 1.0. In practice, deviations from any of them will alter R. Yet the paper essentially ignores points 1–9 and attributes the entire deviation solely to PCR false positives—despite laboratory data showing that PCR false-positive rates are extremely low (nowhere near 86%). The modeling approach is naïve and built on implausible assumptions, many demonstrably false. I have no idea how this paper passed peer review; its conclusions are not supported by its analysis, which rests on a fundamentally unsound premise. The resulting claim that 86% of PCR positives were not true infections is scientifically indefensible.

What is happening to so many COVID-conscious people has a name: social exclusion. If this is a new feeling for you, it can be incredibly confusing and painful. For many of us who have always been "outsiders," the mask is just one more reason on a long list. But now you're feeling it: the conversations that die, the invitations that stop, the silence where your concerns used to be. This is not an accident. Our society uses exclusion—excommunication, exile, ostracism—as a penalty for non-conformity. It is a tool to enforce the status quo. The pain you feel is real. It's called an exclusion injury, and it registers in the brain similarly to physical pain. Your body is telling you a truth: that connection is being severed as a punishment. This is article discusses the research of Matthew Lieberman: inknownative.com/blog/exclus… Link to Lieberman's book: amazon.com/Social-Why-Brains… @TMaritanoAquino

Multiple new lawsuits have been filed against OpenAI — four of them involve suicides.

I'm still pissing myself over the one you posted 😂😂😂 Population level with 76 people 😂 Not even the right subject 😂

This is literal nonsense. AJ is a fraud. Mortality has been under 2019 levels since 2024. The "mass disabling event" must have skipped Sweden. And the anti-vaxxers in your comments are just as delusional.

This is literal nonsense. AJ is a fraud. Mortality has been under 2019 levels since 2024. The "mass disabling event" must have skipped Sweden. And the anti-vaxxers in your comments are just as delusional.

Risk of myocarditis is higher after Covid infection than after vaccine That's a tricky one for anti vaxxers to spin thelancet.com/journals/lanch…

IL-6 and IL-8 elevations after co-administration of COVID-19 and influenza vaccines are associated with lower anti-spike IgG titers at three and six months post-vaccination 🔥For those still in doubt: don’t take both vaccines together( →4-6 weeks). ➡️"Coordinated activation of cytokines 5 days after dual COVID-19 and Flu vaccination." ➡️"The IL-6 and IL-8 increase negatively correlated with anti-S IgG at 3- and 6-months." ➡️Subsequently the "Inflammatory cytokine response may limit persistence of vaccine-induced antibody response." ‼️So, co-administration may impair long-term COVID-19 antibody persistence due to early inflammatory cytokines (e.g., IL-6, IL-8) negatively correlating with mid-term IgG titers. sciencedirect.com/science/ar…