Clearance of waste products made by cells in your brain, spinal cord & eyes (!) occurs mainly during deep sleep (a process called glymphatic clearance b/c it involves glia & resembles lymphatic clearance in the body). Glymphatic clearance is essential to reduce daytime brain fog, “bags under eyes” & offset dementia. Glymphatic clearance is most effective when you: 1) sleep on your side (either side) 2) elevate your head & neck ~5-10 degrees 3) keep a regular bed time (+/-30min fine) 4) avoid food w/in ~2hrs* of bedtime (but don’t try to sleep w/gnawing hunger) 5) do high intensity exercise earlier that day 6) walk, rebound* and/or do at-clavicle lymphatic massage** when you wake up

To be clear, XPeng Iron's catwalk requires precise coordination of 82 degrees of freedom for fluid/human-like motion. Its advanced balance algo to handle dynamic swaying w/out falling & real-tim posture adjustments is a huge technical achievements & progress. My question is progress for what? The decision makers prioritise showmanship over practical tasks like object manipulations or navigation. This direction consumes excess energy on aesthetic movements irrelevant to efficiency. It also adds unnecessary complexity that doesn't enhance utility in real-world applications. So - yes, technically impressive; but if I was an XPeng investor I'd feel nervous by now. As a keen observer in the robotics development, I think/believe that efficiency/scalability will win. Don't forget scalability also means data advantages too.

R.I.P Uber. Tesla Robotaxi is over 5 times cheaper than UberX in Austin, TX (without factoring in tips).

Just like it's really hard to downgrade your lifestyle after you got used to a certain level of comfort, it's really hard to compromise on your relationships once you realize that there are actually a lot of thoughtful, smart, generous people out there, people who will never bring any drama and anxiety into your life, only joy and gratitude for the opportunity to connect with such kindred spirits.

I experienced something different

I'm not taking a stance on whether inflammation drives cancer, but I will say it's very true that GLP-1 drugs reduce inflammation—a lot! Tirzepatide at any dose greatly reduced levels of high-sensitivity C-reactive protein and interleukin-6, two important inflammation markers:

looool

I’ve designed software, backed startups and helped founders. Now I’m writing fiction. This piece is from a collection of fables I began this year. How we do one thing is how we do everything. For people with 11 quiet minutes. Enjoy. docs.soleio.com/keeper

Self actualization, expedition, lifelong accumulation of knowledge, creating for sake of creating

looool

I was I could tell my younger self that... one day, without warning, it just gets better. You smile again for no reason. You feel hope again. If you're in it right now, I promise you... give it time.

Goldman Sachs has released a shocking report summarizing the job types that AI will take over. It states that AI has the potential to automate the work equivalent to 300 million people worldwide. Those particularly affected are knowledge workers, with ・Administrative and support: 46% ・Legal: 44% ・Architecture and engineering: 37% On the other hand, the impact on physical labor such as construction and maintenance is less than 6%. The result is that AI will first replace knowledge workers.

Living somewhere with clean air will soon become the top consideration where to move to as we become more aware of the dangers of air pollution

Fun fact: Vapes don’t actually vaporize the liquid. They aerosolize it. That is, what you inhale isn’t a true vapor (a gas), but a cloud of tiny liquid droplets and solid particles suspended in air, which then deposit deep into your lungs.

THE HIGHEST NOTED VIBRATION IS AUTHENTICITY. It vibrates even higher than love. Imagine that—love is not the highest vibrational force. Truth is. When you're authentic, you're radiating a frequency of pure truth. You're not holding back any part of yourself. This creates a profound sense of clarity and perfect alignment within you. Truth is a frequency. It resonates. Truth can come from anywhere—there is nothing that does not carry its own spark of truth. Because without that spark, nothing can exist. Not even falseness. Therefore, the wise person is the one who knows how to learn truth from every person and discover the truth of each thing. We must open ourselves to a higher reality, to see the spirit within the matter, to raise our consciousness until our entire perception of reality is transformed... and the divine within all creation is finally revealed. ~ Mazhar ✨🙌🏾💫

One of the best things you can do for yourself is to get custom molded hearing aids. Take them with you everywhere you go. Modern society is way too loud, wrecking our hearing. Wear your hearing protection at social gatherings, restaurants, concerts, movies, etc. You will be surprised to learn how frequently you're exposed to hearing-loss induced environments. You don’t want hearing loss. It will cause your brain to shrink at around 1.3x the speed. It increases dementia risk by 2-5x depending on severity. It can also lead to depression, social isolation and mortality. If you want to build your intuition on how loud environments are, download this app and start sampling situations.

Hinton is no longer afraid of superintelligence.

What if your hand could move, even when it’s away from you? BrainCo’s wireless bionic hand makes it real. Mind controls, hand follows thought! Powered by non-invasive brain-computer interface (BCI) technology. Users can perform delicate tasks like single-finger typing and writing. Helps people with limb loss regain control of everyday life through neural decoding and AI

This is exciting...5-MeO-DMT just got FDA breakthrough designation for treatment resistant depression. 193 ppl with moderate-to-severe depression 38 sites 6 countries Patients received either 12 mg (n=73), 8 mg (n=46), or a low-dose comparator of 0.3 mg (n=74), which served as a placebo control. Efficacy Findings + at day 29 post-dosing, a single 12 mg dose reduced depression scores by 11.1 points (MADRS scale 0-60), compared to a 5.8-point reduction with the low 0.3 mg dose. + the 8 mg dose demonstrated equivalent efficacy, suggesting its potential sufficiency for therapeutic benefit. + effects of both 12 mg and 8 mg therapeutic doses were statistically significant compared to the low 0.3 mg dose, starting two days after treatment and peaking at 29 days post-treatment. + both 12 mg and 8 mg single doses exhibited durable effects, with mean depression score reductions of 10.2 and 10.8 points, respectively. Both were significantly greater than the 5.2-point reduction observed with the low 0.3 mg dose. Safety Findings + 5-MeO-DMT was well tolerated at all doses, with over 99% of adverse effects being mild or moderate and no serious adverse effects reported. + dose related increases in nausea, headache, blood pressure, and anxiety suggest the 8 mg dose was better tolerated than the 12 mg dose. + no suicide-related safety signals or concerns were observed. + most treated patients were deemed ready to go home within 90 minutes of treatment Findings from the phase 2a open-label study, using 12 mg and 8 mg doses spaced two weeks apart, showed similar results. These included a rapid decrease in depression score by day 2, maximal improvement at day 22, with a durable effect lasting over 12 weeks of follow-up.

“The one thing money can’t buy,” said Luckey, “is people who liked you before you had money. I’m very lucky that I met my wife back when I had literally nothing. When we met, I had less than $300 in my bank account … I probably should have gotten married, should have married her when I was 16. Looking back, I think that’s probably my radical belief.” tabletmag.com/feature/americ…